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National Institutes of Health StrokeNet During the Time of COVID-19 and Beyond
 
  Announcement:  
Template letter to NIH StrokeNet Principal Investigators for restarting trial enrollment.
Within a month of suspension of enrollment, two trials had submitted a plan for reopening enrollment to the CIRB and a template letter for restarting trials was provided to all trial PIs to craft a trial-specific plan and request to CIRB to restart enrollment.
NIH StrokeNet Request to Reopen
 

GET INVOLVED:

  1. StrokeNet Concept Synopsis v3.0 Updated 1/31/2018
  2. Process for Solicitation and Review of Clinical Trials
  3. NINDS Stroke Trials Network
  4. StrokeNet Working Group Slide October 2019
  5. Proposal Development Process Flowchart v8 - June 2017

Funding Announcements:

  1. NOT-NS-14-043: Notice of Clarification of NINDS Policy for the Submission of Multi-site Clinical Trials in Stroke Treatment, Recovery, or Prevention
  2. PAR-20-285 NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)  July 29, 2020
  3. PAR-17-277 NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention Infrastructure Resource Access (X01)  Expired 1/24/2018
  4. PAR-18-563: NIH StrokeNet Small Business Innovation Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (U44 - Clinical Trial Optional)   Reissue 1/9/2018

NIH StrokeNet Funding Announcement:

  1. NOT-NS-17-019_ Notice of Intent to Publish a Funding Opportunity Announcement for NINDS StrokeNet Regional Coordinating Stroke Centers (U24)  Announcement Date May 2017
  2. StrokeNet Submission FAQs

Administrative Documents:

  1. StrokeNet Standard Operating Procedures (SOP's), Administrative and Good Clinical Practice 
  2. StrokeNet Start Up Site Communication Process Flowchart 6.4.2020
  3. Letters:
  4. Trial CTA Attachment 5 Documents
  5.  Competing Trials in StrokeNet Guidance April 2019
  6. MTAs & Changes in the Network 
  7. DSMB Schedule for Current NIH StrokeNet Trials 12.18.20

Central IRB:

  1. Institution-vs-IRB-responsibilities

Network Publications:

  1. Multiomic markers stroke Nat Rev Neurol 2020
  2. AF-SCREEN white paper post-stroke AF monitoring Circulation 2019
  3. Atrial myopathy review JACC Basic to Translational 2019
  4. Carotid revascularization and medical management for asymptomatic carotid stenosis - Hemodynamics (CREST-H): Study Design and rationale.
  5. A pragmatic, adaptive clinical trial design for a rare disease: The FOcal Cerebral Arteriopathy Steroid (FOCAS) trial
  6. The Utility of Domain-Specific End Points in Acute Stroke Trial
  7. Stroke Recovery and Rehabilitation Research: Issues, Opportunities, and the National Institutes of Health StrokeNet
  8. Imaging in StrokeNet: Realizing the Potential of Big Data
  9. Intense Arm Rehabilitation Therapy Improves the Modified Rankin Scale Score: Association Between Gains in Impairment and Function
  10. Efficacy of Home-Based Telerehabilitation vs In-Clinic Therapy for Adults After Stroke A Randomized Clinical Trial 
  11. National Institutes of Health StrokeNet During the Time of COVID-19 and Beyond
  12. Obstructive Sleep Apnea in Adults
  13. Recommendations for Clinical Trials in ICH: The Second Hemorrhagic Stroke Academia Industry Roundtable.
  14. Sleep for Stroke Management and Recovery Trial (Sleep SMART): Rationale and methods
  15. National Institute of Health StrokeNet Training Core
  16. The AtRial cardiopathy and antithrombotic drugs in prevention after cryptogenic stroke randomized trial: Rationale and methods.
  17. Efficacy of home-based telerehabilitation vs in-clinic therapy for adults after stroke: A randomized clinical trial.
  18. Thrombectomy for Strole at 6 to 16 Hours with Selection by Perfusion Imaging 
  19. Study-aims-to-learn-more-about-silent-infarction-cognitive-decline-linked-to-silent-stroke
  20. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging. 
  21.  Stroke Recovery and Rehabilitation Research Issues, Opportunities, and the National Institutes of  Health StrokeNet.
     
  22. StrokeNet Takes Off National Institute of Neurological Disorders and Stroke Organizational Update. 
     
  23. The NIH StrokeNet A Users Guide.
  24. Imaging in StrokeNet Realizing the Potential of Big Data.

Research Practice Publications:

  1. How Nurses Can Partner With National Institutes of Health StrokeNet to Deliver Best Research and Care to Stroke Patients. Stroke. 2017;STROKEAHA.117.017872 . Originally published December 4, 2017. Jamey Frasure, Judith Spilker
  2. Power of an Adaptive Trial Design for Endovascular Stroke Studies: Simulations Using IMS (Interventional Management of Stroke) III Data. Stroke. 2016;47:2931-2937. Originally published November 15, 2016
    Maarten G. Lansberg, Ninad S. Bhat, Sharon D. Yeatts, Yuko Y. Palesch, Joseph P. Broderick, Gregory W. Albers, Tze L. Lai and Philip W. Lavori
  3. Stroke Treatment Academic Industry Roundtable: The Next Generation of Endovascular Trials. Stroke. 2016;47:2656-2665. Originally published September 1, 2016
    Tudor G. Jovin, Gregory W. Albers, David S. Liebeskind and for the STAIR IX Consortium
  4. Stroke Treatment Academic Industry Roundtable Recommendations for Individual Data Pooling Analyses in Stroke. 2016;47:2154-2159. Originally published July 12, 2016
    Kennedy R. Lees, Pooja Khatri, for the STAIR IX Collaborators