Frederik Denorme, PhD, MS
ISTH2020:
Hyperglycemia primes procoagulant platelet formation and exacerbates ischemic stroke independent of platelet glucose uptake. Frederik Denorme; Irina Portier; Yasuhiro Kosak1 and Robert A. Campbell
Guo L., Shen S., Rowley J.W., Tolley N.D., Jia W., Manne BK., McComas K.N., Bolingbroke B., Kosaka Y., Krauel K.,
Denorme F., Jacob SP, Eustes A.S, Campbell R.A., Middleton E.A., He X., Brown S.M., Morrell C.N., Weyrich A.S., Rondina M.T. Platelet MHC Class I Mediates CD8+ T Cell Suppression During Sepsis. Blood. 2021. https://doi.org/10.1182/blood.2020008958.
Othman M., Cormier M., Barnes G.D., Comer S.P., Connors J.M., Denorme F., Khorana A.A., Las Casas P.H., Morla S., Muia J., Ní Áinle F., Taylor K.A., van der Wal D.E., Weyand A.C., Lavin M.; ISTH Registration, Marketing teams. Harnessing Twitter to empower scientific engagement and communication: The ISTH 2020 virtual congress experience. Res Pract Thromb Haemost. 2021 Mar 8;5(2):253-260.
Denorme F., Martinod K., Vandenbulcke A., Denis C.V., Lenting P.J., Deckmyn H., Vanhoorelbeke K., De Meyer S.F. The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice. Haematologica. 2021 Mar 1;106(3):819-828.
Denorme F., Portier I., Kosaka Y., Campbell R.A. Hyperglycemia exacerbates ischemic stroke outcome independent of platelet glucose uptake. J Thromb Haemost. 2021 Feb;19(2):536-546.
*
Bouck E.G., *Denorme F., Holle L.A. , Middelton E.A. , Blair AM, de Laat B. , Schiffman J.D., Yost C.C., RondinaM.T., °Wolberg A.S., °Campbell R.A. COVID-19 and Sepsis Are Associated With Different Abnormalities in Plasma Procoagulant and Fibrinolytic Activity. Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):401-414. *,° indicates equal contribution*
Denorme F., Manne B.K., Portier I., Petrey A.C., Middleton E., Kile B.T., Rondina M.T., Campbell R.A. COVID-19 patients exhibit reduced procoagulant platelet responses. J Thromb Haemost. 2020; 18:3067–3073.*
*Manne B.K., *
Denorme F., *Middleton E.A., Portier I., Rowley J.W., Stubben C.J., Petrey A.C., Tolley N.D., Guo L., Cody M.J., Weyrich A.S., Yost C.C., Rondina M.T., Campbell R.A. Platelet Gene Expression and Function in COVID-19 Patients. Blood. 2020; 136(11): 1317–1329. * indicates equal contribution
Middleton E.A., He X.Y.,
Denorme F., Campbell R.A., Ng D., Salvatore S.P., Mostyka M., Baxter-Stoltzfus A., Borczuk A.C., Loda M., Cody M.J., Manne B.K., Portier I., Harris E., Petrey A.C., Beswick E.J., Caulin A.F., Iovino A., Abegglen L.M., Weyrich A.S., Rondina M.T., Egeblad M., Schiffman J.D., Yost C.C. Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome. Blood. 2020; 136(10):1169-1179.
Denorme F., Martinod K., Vandenbulcke A., Denis C.V., Lenting P.J., Deckmyn H., Vanhoorelbeke K., De Meyer S.F. The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice. Haematologica. 2020 Feb 27.
Denorme F., Manne B.K., Portier I., Eustes A.S., Kosaka Y., Kile B.T., Rondina M.T., Campbell R.A. Platelet necrosis mediates ischemic stroke outcome in mice. Blood. 2020 Feb 6;135(6):429-440.
Staessens S., Denorme F., François O., Desender L., Dewaele T., Vanacker P., Deckmyn H., Vanhoorelbeke K., Andersson T., De Meyer SF. Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance. Haematologica. 2020 Jan 31;105(2):498-507.
Denorme F., Vanhoorelbeke K., De Meyer S.F. von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke. Front Immunol. 2019 Dec 17;10:2884. doi: 10.3389/fimmu.2019.02884.