Skip To The Main Content
Surgery
NIH STROKENET: ACUTE INTERVENTIONAL STROKE TRIALS

Treatments for acute stroke include IV t-PA, stroke centers, stroke units, endovascular thrombectomy devices for selected patients, nimodipine for subarachnoid hemorrhage, and aneurysm coiling and clipping for ruptured aneurysms. Intracerebral hemorrhage has proven to be the most challenging for effective treatments; however recent research has shown promise.

CURRENT ACUTE INTERVENTIONAL TRIAL WEBSITES


 RHAPSODY2_logo rectangular   RHAPSODY-2 Trial:  Recombinant variant of Human Activated Protein C (APC), in combination with tPA in acute hemispheric ischemic stroke
     
MOST Trial
  MOST Trial:  Mult-Arm Optimization of Stroke Thrombolysis
     
FASTEST FinalLogo-01
  FASTEST Trial: rFVIIa for Acute Hemorrhagic Stroke Administered at Earliest Time Trial
     
MISTIE_III   MISTIE-III Trial: Minimally Invasive Surgery Plus rt-PA for Intracerebral Hemorrhage Evacuation
     

ACUTE INTERVENTIONAL TRIAL SUMMARIES

  • RHAPSODY-2: 3K3A-APC following administration of thrombolysis, mechanical thrombectomy, or both, in subjects with moderate to severe acute ischemic stroke

  • MOST: MULTI-ARM OPTIMIZATION OF STROKE THROMBOLYSIS STROKE TRIAL

  • DEFUSE 3: ENDOVASCULAR THERAPY FOLLOWING IMAGING EVALUATION FOR ISCHEMIC STROKE 3

  • MISTIE III: MINIMALLY INVASIVE SURGERY PLUS rt-PA FOR ICH EVACUATION

  • iDEF: STUDY OF DEFEROXAMINE MESYLATE IN INTRACEREBRAL HEMORRHAGE