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NIH StrokeNet (NSTN) is a National Institute of Neurological Disorders and Stroke (NINDS)/ NIH initiative to conduct Phase I/II and III trials in stroke prevention, treatment and recovery. All proposals are evaluated for mission relevance and institute priority by NINDS and for network feasibility by the NSTN executive and steering committees. The scientific review of the proposal occurs after the grant application has been submitted for peer- and council-review. Funding decisions are made based on the results of those reviews. To find a Regional Coordinating Center near you click here or contact the National Coordinating Centers toll free number (855) 472-0072.

For NINDS response to StrokeNet questions, receipt of concept proposals, etc. please send your emails to the NINDS group mailbox:


  1. StrokeNet Concept Synopsis V2.0 Updated 1/31/2018
  2. Process for Solicitation and Review of Clinical Trials
  3. NINDS Stroke Trials Network
  4. StrokeNet Working Group Slide 20-Mar 2017

Funding Announcements:

  1. NOT-NS-14-043: Notice of Clarification of NINDS Policy for the Submission of Multi-site Clinical Trials in Stroke Treatment, Recovery, or Prevention
  2. PAR-18-561: NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (U01 Clinical Trial Optional)   Reissue 1/9/2018
  3. PAR-17-277 NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention Infrastructure Resource Access (X01)  Expired 1/24/2018
  4. PAR-18-563: NIH StrokeNet Small Business Innovation Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (U44 - Clinical Trial Optional)   Reissue 1/9/2018

NIH StrokeNet Funding Announcement:

  1. NOT-NS-17-019_ Notice of Intent to Publish a Funding Opportunity Announcement for NINDS StrokeNet Regional Coordinating Stroke Centers (U24)  Announcement Date May 2017
  2. StrokeNet Submission FAQs

Administrative Documents:

  1. StrokeNet Standard Operating Procedures, Administrative and Good Clinical Practice  Revised ADM 2 - 5/26/2017
  2. 2014-04-04_ Reliance Authorization Agreement final RCC template
  3. 2013-12-30 FINAL APPROVED NIH StrokeNet Sub award Master Trial Agreement
  4. Quarterly Activity Report Template 13-Jul-16

NCC Notice Of Awards:

  1. Year 1:
    1. 2013-09-22-NOA 1U01NS086872-01
    2. 2013-09-27-NOA 1U01NS086872-01-REVISED
  2. Year 2: 2014-07-11-NOA 1U01NS086872-02
  3. Year 3: 2015-08-10-NOA 1U01NS086872-03
  4. Year 4: 2016-9-23 NOA 4U01NS086872-04_REVISED

Network Publications:

  1. Stroke Recovery and Rehabilitation Research Issues, Opportunities, and the National Institutes of Health StrokeNet. Stroke. 2017;48:813-819 Originally published February 7, 2017
    Steven C. Cramer, MD; Steven L. Wolf, PhD; Harold P. Adams, Jr, MD; Daofen Chen, PhD; Alexander W. Dromerick, MD; Kari Dunning, PT, PhD; Caitlyn Ellerbe, PhD; Andrew Grande, MD; Scott Janis, PhD; Maarten G. Lansberg, MD; Ronald M. Lazar, PhD; Yuko Y. Palesch, PhD; Lorie Richards, PhD; Elliot Roth, MD; Sean I. Savitz, MD; Lawrence R. Wechsler, MD; Max Wintermark, MD; Joseph P. Broderick, MD
  2. StrokeNet Takes Off National Institute of Neurological Disorders and Stroke Organizational Update.  Stroke. 2016;47:e51-e52 Originally published January 26, 2016
    Meghan Mott, Scott Janis, Walter J. Koroshetz
  3. The NIH StrokeNet A Users Guide.  Stroke. 2016;47:301-303 Originally published December 29, 2015
    Broderick JP, Palesch YY, Janis LS for the National Institutes of Health StrokeNet Investigator
  4. Imaging in StrokeNet Realizing the Potential of Big Data. Stroke. 2015;46:2000-2006. Originally published June 4 2015
    David S. Liebeskind, Gregory W. Albers, Karen Crawford, Colin P. Derdeyn, Mark S. George, Yuko Y. Palesch, Arthur W. Toga, Steven Warach, Wenle Zhao, Thomas G. Brott, Ralph L. Sacco, Pooja Khatri, Jeffrey L. Saver, Steven C. Cramer, Steven L. Wolf, Joseph P. Broderick and Max Wintermark

Research Practice Publications:

  1. How Nurses Can Partner With National Institutes of Health StrokeNet to Deliver Best Research and Care to Stroke Patients. Stroke. 2017;STROKEAHA.117.017872 . Originally published December 4, 2017. Jamey Frasure, Judith Spilker
  2. Power of an Adaptive Trial Design for Endovascular Stroke Studies: Simulations Using IMS (Interventional Management of Stroke) III Data. Stroke. 2016;47:2931-2937. Originally published November 15, 2016
    Maarten G. Lansberg, Ninad S. Bhat, Sharon D. Yeatts, Yuko Y. Palesch, Joseph P. Broderick, Gregory W. Albers, Tze L. Lai and Philip W. Lavori
  3. Stroke Treatment Academic Industry Roundtable: The Next Generation of Endovascular Trials. Stroke. 2016;47:2656-2665. Originally published September 1, 2016
    Tudor G. Jovin, Gregory W. Albers, David S. Liebeskind and for the STAIR IX Consortium
  4. Stroke Treatment Academic Industry Roundtable Recommendations for Individual Data Pooling Analyses in Stroke. 2016;47:2154-2159. Originally published July 12, 2016
    Kennedy R. Lees, Pooja Khatri, for the STAIR IX Collaborators

Related Links:

Other NIH Networks conducting trials in neurological disease: